Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | GRK2 | P25098 | 3/20 | 0.45 |
| ▸ | GRK3 | P35626 | 2/20 | 0.45 |
| ▸ | PREP | P48147 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18666152 | 0.91 | KDR (0.53) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL18666250 | 0.90 | KDR (0.48) | DGAT2POLBHTTKDRPREP | |
| SCHEMBL18666244 | 0.84 | PREP (0.46) | DGAT2POLBPREPDPP7MMP1 | |
| SCHEMBL18666437 | 0.82 | MEN1 (0.48) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL18666264 | 0.81 | KDR (0.58) | MITFALDH1A1POLBKDRMMP1 | |
| SCHEMBL18666243 | 0.80 | ADRA2C (0.50) | ALDH1A1POLBMAPK1PREPDPP7 | |
| SCHEMBL18666447 | 0.76 | KDR (0.51) | MITFALDH1A1POLBMAPK1HTT | |
| SCHEMBL18666157 | 0.76 | ALDH1A1 (0.48) | MITFALDH1A1POLBKDRHDAC2 | |
| SCHEMBL21675715 | 0.74 | MEN1 (0.56) | MITFALDH1A1POLBMMP1 | |
| SCHEMBL24724038 | 0.74 | KDR (0.51) | ALDH1A1HTTKDRRAF1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |
| US-11345656-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210078938-A1 | PCNA INHIBITORS | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2021-03-18 | — | — | US | disclosed |
| US-10913706-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200216386-A1 | PCNA INHIBITORS | UNITED STATES GOVERNMENT | 2020-07-09 | — | — | US | disclosed |
| US-10550070-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2020-02-04 | — | — | US | disclosed |
| WO-2017049206-A1 | PCNA INHIBITORS | CITY OF HOPE (US) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913706-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | DGAT2 2424/4885MITF 2267/4885ALDH1A1 3079/4885 |
| US-20210078938-A1 | PCNA INHIBITORS | PCNA, MKI67, PCLAF | DGAT2 2424/4885MITF 2267/4885ALDH1A1 3079/4885 |
| US-11345656-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | DGAT2 2424/4885MITF 2267/4885ALDH1A1 3079/4885 |
| US-10550070-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | DGAT2 2424/4885MITF 2267/4885ALDH1A1 3079/4885 |
| US-20200216386-A1 | PCNA INHIBITORS | PCNA, MKI67, PCLAF | DGAT2 2424/4885MITF 2267/4885ALDH1A1 3079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.