Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18666146 | 0.91 | ADRA2C (0.54) | ALDH1A1ADRA2CSMN1; SMN2L3MBTL1GAA | |
| SCHEMBL29660113 | 0.91 | ADRA2C (0.54) | ALDH1A1ADRA2CSMN1; SMN2L3MBTL1GAA | |
| SCHEMBL18666244 | 0.90 | PREP (0.46) | ADRA2CL3MBTL1GAAPOLBCYP19A1 | |
| SCHEMBL18666199 | 0.88 | DEGS1 (0.49) | ALDH1A1KDM4EADRA2CL3MBTL1GAA | |
| SCHEMBL18666149 | 0.87 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTMEN1LMNA | |
| SCHEMBL21675770 | 0.85 | ALDH1A1 (0.45) | ALDH1A1KDM4EADRA2CL3MBTL1GAA | |
| SCHEMBL18666094 | 0.85 | RAB9A (0.47) | ADRA2CHDAC2L3MBTL1GAAPOLB | |
| SCHEMBL18666264 | 0.85 | KDR (0.58) | ALDH1A1KDM4EMAPTKDRL3MBTL1 | |
| SCHEMBL18666150 | 0.84 | MTNR1B (0.47) | ALDH1A1KDM4EADRA2CMAPTL3MBTL1 | |
| SCHEMBL18666152 | 0.84 | KDR (0.53) | ALDH1A1KDM4EHDAC2KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |
| US-11345656-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2022-05-31 | — | — | US | disclosed |
| US-20210078938-A1 | PCNA INHIBITORS | THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2021-03-18 | — | — | US | disclosed |
| US-10913706-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2021-02-09 | — | — | US | disclosed |
| US-20200216386-A1 | PCNA INHIBITORS | UNITED STATES GOVERNMENT | 2020-07-09 | — | — | US | disclosed |
| US-10550070-B2 | PCNA inhibitors | CITY OF HOPE (US) | 2020-02-04 | — | — | US | disclosed |
| WO-2017049206-A1 | PCNA INHIBITORS | CITY OF HOPE (US) | 2017-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10913706-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | ALDH1A1 3079/4885KDM4E 2125/4885ADRA2C 4716/4885 |
| US-20210078938-A1 | PCNA INHIBITORS | PCNA, MKI67, PCLAF | ALDH1A1 3079/4885KDM4E 2125/4885ADRA2C 4716/4885 |
| US-11345656-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | ALDH1A1 3079/4885KDM4E 2125/4885ADRA2C 4716/4885 |
| US-10550070-B2 | PCNA inhibitors | PCNA, MKI67, PCLAF | ALDH1A1 3079/4885KDM4E 2125/4885ADRA2C 4716/4885 |
| US-20200216386-A1 | PCNA INHIBITORS | PCNA, MKI67, PCLAF | ALDH1A1 3079/4885KDM4E 2125/4885ADRA2C 4716/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.