Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500499 | 0.88 | L3MBTL1 (0.59) | MEN1KMT2AEGLN1CNR1MAOB | |
| SCHEMBL14395788 | 0.86 | LMNA (0.57) | MEN1KMT2AEGLN1CNR1MAOB | |
| SCHEMBL23417254 | 0.84 | EGLN1 (0.51) | MEN1KMT2AEGLN1CNR1MAOB | |
| SCHEMBL280282 | 0.83 | EGLN1 (0.57) | EGLN1MAOBRAB9A | |
| SCHEMBL10228354 | 0.81 | CNR1 (0.57) | MEN1KMT2AEGLN1CNR1MAOB | |
| SCHEMBL14124612 | 0.80 | SMN1; SMN2 (0.53) | MEN1KMT2AEGLN1CNR1MAOB | |
| SCHEMBL107387 | 0.78 | P2RX7 (0.53) | MEN1KMT2AEGLN1MAOBRAB9A | |
| SCHEMBL17298863 | 0.76 | EGLN1 (0.50) | EGLN1CNR1MAOBRAB9ASMN1; SMN2 | |
| SCHEMBL6207746 | 0.76 | L3MBTL1 (0.70) | MEN1KMT2ARAB9APOLBSMN1; SMN2 | |
| SCHEMBL19440768 | 0.76 | HIF1A (0.67) | MEN1KMT2ARAB9APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017045750-A1 | COMPOUNDS AS ASIC INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-03-23 | — | — | WO | disclosed |