Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 4/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | RARB | P10826 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | TACR2 | P21452 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18668584 | 1.00 | S1PR1 (0.46) | S1PR1S1PR3S1PR4S1PR5SPHK2 | |
| SCHEMBL30020662 | 0.86 | ABCB1 (0.47) | S1PR1S1PR3S1PR4S1PR5SPHK2 | |
| SCHEMBL30020195 | 0.86 | ABCB1 (0.47) | S1PR1S1PR3S1PR4S1PR5SPHK2 | |
| SCHEMBL2316672 | 0.82 | BDKRB2 (0.54) | S1PR5SPHK2ALDH1A1BDKRB2 | |
| SCHEMBL15798198 | 0.82 | BDKRB2 (0.54) | S1PR5SPHK2ALDH1A1BDKRB2 | |
| SCHEMBL15718828 | 0.73 | F2 (0.33) | BDKRB2 | |
| SCHEMBL23236378 | 0.73 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR5SPHK2 | |
| SCHEMBL29385583 | 0.72 | BDKRB2 (0.51) | HRH3BDKRB2 | |
| SCHEMBL28995867 | 0.70 | ABCB1 (0.58) | MEN1KMT2ABDKRB2 | |
| SCHEMBL30421047 | 0.70 | ABCB1 (0.58) | MEN1KMT2ABDKRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999693-B2 | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-06-04 | — | — | US | disclosed |
| US-20230122855-A1 | Synthetic Sphingolipid-Like Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2023-04-20 | — | — | US | disclosed |
| US-10995068-B2 | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-05-04 | — | — | US | disclosed |
| US-20180265464-A1 | Synthetic Sphingolipid-Like Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-09-20 | — | — | US | disclosed |
| EP-3352753-A1 | SYNTHETIC SPHINGOLIPID-LIKE MOLECULES, DRUGS, METHODS OF THEIR SYNTHESIS AND METHODS OF TREATMENT | The Regents of The University of California (US) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017053990-A1 | SYNTHETIC SPHINGOLIPID-LIKE MOLECULES, DRUGS, METHODS OF THEIR SYNTHESIS AND METHODS OF TREATMENT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230122855-A1 | Synthetic Sphingolipid-Like Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment | SGMS1, SGMS2, SMPD1 | S1PR1 10/4885S1PR3 17/4885S1PR4 18/4885 |
| US-10995068-B2 | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment | SGMS1, SGMS2, SMPD1 | S1PR1 10/4885S1PR3 17/4885S1PR4 18/4885 |
| US-11999693-B2 | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment | SGMS1, SGMS2, SMPD1 | S1PR1 10/4885S1PR3 17/4885S1PR4 18/4885 |
| US-20180265464-A1 | Synthetic Sphingolipid-Like Molecules, Drugs, Methods of Their Synthesis and Methods of Treatment | SGMS1, SGMS2, SMPD1 | S1PR1 10/4885S1PR3 17/4885S1PR4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.