Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11888514 | 0.80 | HDAC6 (0.66) | NOS1HDAC6GLAL3MBTL1ROCK1 | |
| SCHEMBL104360 | 0.76 | NOS1 (1.00) | NOS1GLAL3MBTL1ROCK1BTK | |
| SCHEMBL18669085 | 0.76 | NOS1 (0.60) | NOS1HDAC6ROCK1CLK4ROCK2 | |
| SCHEMBL7571385 | 0.75 | GLA (0.55) | NOS1HDAC6GLAL3MBTL1ROCK1 | |
| SCHEMBL15427016 | 0.74 | BRD4 (0.57) | NOS1HDAC6GLAL3MBTL1ROCK1 | |
| SCHEMBL21863628 | 0.72 | GLA (0.58) | NOS1HDAC6GLAL3MBTL1ROCK1 | |
| SCHEMBL20239491 | 0.72 | GLA (0.63) | NOS1HDAC6GLAL3MBTL1ROCK1 | |
| SCHEMBL18668974 | 0.71 | ROCK2 (0.67) | NOS1ROCK1AURKAPRKXCDK5 | |
| SCHEMBL11509957 | 0.70 | MEN1 (0.50) | HDAC6GLAL3MBTL1ROCK2ALDH1A1 | |
| SCHEMBL30849358 | 0.68 | MEN1 (0.51) | NOS1GLAL3MBTL1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |
| WO-2017049409-A1 | COMPOSITIONS FOR PROMOTING READTHROUGH OF PREMATURE TERMINATION CODONS, AND METHODS OF USING THE SAME | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2017-03-30 | — | — | WO | disclosed |