SCHEMBL18669403

SCHEMBL18669403

CC(c1ccccc1)C1NCCc2c1[nH]c1ccccc21

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 6/20 0.58
CYP3A4 P08684 1/20 0.58
CYP2D6 P10635 1/20 0.58
CYP2C19 P33261 1/20 0.58
HTR2A P28223 2/20 0.58
HTR2C P28335 2/20 0.58
MAPKAPK2 P49137 1/20 0.54
GRIN2B Q13224 1/20 0.53
MEN1 O00255 2/20 0.49
KMT2A Q03164 2/20 0.49
DRD2 P14416 2/20 0.47
CHRM4 P08173 3/20 0.46
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
PRMT5 O14744 2/20 0.44
EGFR P00533 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21326157 0.86 HTR7 (0.60) HTR7CYP3A4CYP2D6CYP2C19HTR2A
SCHEMBL29375692 0.80 HTR7 (0.60) HTR7CYP3A4CYP2D6CYP2C19HTR2A
SCHEMBL7490193 0.77 HTR7 (0.72) HTR7CYP3A4CYP2D6CYP2C19HTR2A
SCHEMBL8907317 0.76 HTR7 (0.44) HTR7CYP3A4CYP2D6CYP2C19HTR2A
Tetrahydroharman SCHEMBL29630308 0.75 HTR7 (0.65) HTR7CYP3A4CYP2D6CYP2C19MAPKAPK2
Tetrahydroharman SCHEMBL21012020 0.75 HTR7 (0.65) HTR7CYP3A4CYP2D6CYP2C19MAPKAPK2
Tetrahydroharman SCHEMBL7018798 0.75 HTR7 (0.65) HTR7CYP3A4CYP2D6CYP2C19MAPKAPK2
Tetrahydroharman SCHEMBL29630296 0.75 HTR7 (0.65) HTR7CYP3A4CYP2D6CYP2C19MAPKAPK2
SCHEMBL10814283 0.75 HTR7 (0.53) HTR7CYP3A4CYP2D6CYP2C19HTR2A
SCHEMBL8905846 0.74 HTR7 (0.42) HTR7CYP3A4CYP2D6CYP2C19HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630512-B2 Agents for differentiating stem cells and treating cancer MINERVA BIOTECHNOLOGIES CORPORATION (US) 2026-05-19 US disclosed
EP-3600451-B1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORP (US) 2025-12-24 EP disclosed
US-12202799-B2 Agents for differentiating stem cells and treating cancer MINERVA BIOTECHNOLOGIES CORPORATION (US) 2025-01-21 US disclosed
US-20240409515-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION 2024-12-12 US disclosed
US-20240307359-A1 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MINERVA BIOTECHNOLOGIES CORP (US) 2024-09-19 US disclosed
US-11931347-B2 Method of screening for agents for differentiating stem cells MINERVA BIOTECHNOLOGIES CORPORATION (US) 2024-03-19 US disclosed
US-20220242823-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION 2022-08-04 US disclosed
US-20220242823-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION 2022-08-04 US disclosed
US-20210299109-A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS MINERVA BIOTECHNOLOGIES CORPORATION 2021-09-30 US disclosed
US-20210299109-A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS MINERVA BIOTECHNOLOGIES CORPORATION 2021-09-30 US disclosed
US-20210087143-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORP (US) 2021-03-25 US disclosed
US-20210087143-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORP (US) 2021-03-25 US disclosed
EP-3600451-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER Minerva Biotechnologies Corporation (US) 2020-02-05 EP disclosed
WO-2018183654-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MINERVA BIOTECHNOLOGIES CORPORATION (US) 2018-10-04 WO disclosed
US-20180263964-A1 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MINERVA BIOTECHNOLOGIES CORPORATION (US) 2018-09-20 US disclosed
EP-3352566-A2 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS Minerva Biotechnologies Corporation (US) 2018-08-01 EP disclosed
WO-2017053886-A2 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MINERVA BIOTECHNOLOGIES CORPORATION (US) 2017-03-30 WO disclosed
WO-2017053886-A2 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MINERVA BIOTECHNOLOGIES CORPORATION (US) 2017-03-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180263964-A1 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MCL1, CRABP2, MYADM HTR7 3278/4885CYP3A4 4405/4885CYP2D6 4384/4885
US-11931347-B2 Method of screening for agents for differentiating stem cells MCL1, CRABP2, MYADM HTR7 3278/4885CYP3A4 4405/4885CYP2D6 4384/4885
US-20210299109-A1 AGENTS FOR TREATING CANCER AND METHODS FOR IDENTIFYING SAID AGENTS MCL1, CD44, EPCAM HTR7 3547/4885CYP3A4 4476/4885CYP2D6 4379/4885
US-20240307359-A1 METHOD OF SCREENING FOR AGENTS FOR DIFFERENTIATING STEM CELLS MCL1, CRABP2, MYADM HTR7 3278/4885CYP3A4 4405/4885CYP2D6 4384/4885
US-12202799-B2 Agents for differentiating stem cells and treating cancer MCL1, CD44, CRABP2 HTR7 3584/4885CYP3A4 4808/4885CYP2D6 4801/4885
US-20210087143-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 HTR7 3584/4885CYP3A4 4808/4885CYP2D6 4801/4885
US-12630512-B2 Agents for differentiating stem cells and treating cancer MCL1, POU2F1, NES HTR7 2402/4885CYP3A4 3258/4885CYP2D6 3225/4885
US-20240409515-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 HTR7 3584/4885CYP3A4 4808/4885CYP2D6 4801/4885
US-20220242823-A1 AGENTS FOR DIFFERENTIATING STEM CELLS AND TREATING CANCER MCL1, CD44, CRABP2 HTR7 3584/4885CYP3A4 4808/4885CYP2D6 4801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.