Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338236 | 0.82 | CYP11B2 (0.33) | KDM4EALDH1A1POLB | |
| SCHEMBL29379576 | 0.82 | CYP11B2 (0.33) | KDM4EALDH1A1POLB | |
| SCHEMBL16786051 | 0.78 | KDM4E (0.32) | KDM4EALDH1A1POLBEGLN2 | |
| SCHEMBL27794034 | 0.78 | ALOX5AP (0.33) | KDM4EALDH1A1POLBEGLN2 | |
| SCHEMBL2614511 | 0.78 | CYP11B1 (0.35) | KDM4EALDH1A1POLB | |
| SCHEMBL6375598 | 0.74 | ALOX5AP (0.42) | PIK3CD | |
| SCHEMBL6376942 | 0.74 | ALDH1A1 (0.36) | KDM4EALDH1A1POLB | |
| SCHEMBL1336348 | 0.74 | ALOX5AP (0.31) | — | |
| SCHEMBL23677271 | 0.74 | KDM4E (0.30) | KDM4EALDH1A1POLB | |
| SCHEMBL23677296 | 0.74 | KDM4E (0.30) | KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3353155-A1 | PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP | AbbVie Deutschland GmbH & Co. KG (DE) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017050807-A1 | PYRIDYL OR PYRAZINYL COMPOUNDS CARRYING A METHYL-BOUND ALPHA-AMINO ACID AMIDE GROUP | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-30 | — | — | WO | disclosed |
| CN-106083745-A | The synthetic method of 6 fluorine 3 hydroxyl 2 pyrazinamide | 山东百诺医药股份有限公司 | 2016-11-09 | — | — | CN | disclosed |