Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.33 |
| ▸ | CTSA | P10619 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1858388 | 0.91 | TRPV1 (0.49) | MRGPRX4TRPV1MAOAKCNH2 | |
| SCHEMBL1862128 | 0.90 | MRGPRX4 (0.40) | MRGPRX4TRPV1MAOAKCNH2CTSA | |
| SCHEMBL1860856 | 0.89 | TRPV1 (0.41) | MRGPRX4TRPV1FGFR4LRRK2CTSA | |
| SCHEMBL1857549 | 0.87 | TRPV1 (0.41) | MRGPRX4TRPV1MAOAKCNH2LRRK2 | |
| SCHEMBL1862598 | 0.86 | TRPV1 (0.45) | MRGPRX4TRPV1MAOAKCNH2FGFR4 | |
| SCHEMBL1866290 | 0.81 | TRPV1 (0.38) | MRGPRX4TRPV1FGFR4LRRK2CTSA | |
| SCHEMBL1867816 | 0.80 | TRPV1 (0.49) | MRGPRX4TRPV1MAOAKCNH2 | |
| SCHEMBL1866320 | 0.78 | TRPV1 (0.59) | MRGPRX4TRPV1MAOAKCNH2SMN1; SMN2 | |
| SCHEMBL1862355 | 0.78 | MRGPRX4 (0.40) | MRGPRX4TRPV1CTSA | |
| SCHEMBL1862452 | 0.77 | TRPV1 (0.46) | MRGPRX4TRPV1MAOAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-7935702-B2 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2011-05-03 | — | — | US | disclosed |
| US-20060111337-A1 | Substituted biaryl quinolin-4-ylamine analogues | NEUROGEN CORPORATION (US) | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111337-A1 | Substituted biaryl quinolin-4-ylamine analogues | PIGS, GPR52, GPR174 | MRGPRX4 199/4885TRPV1 549/4885MAOA 582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.