Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 8/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1867981 | 0.89 | ADORA1 (0.58) | ADORA1P2RX3 | |
| SCHEMBL1865499 | 0.82 | ADORA1 (0.36) | ADORA1MAPTADORA2B | |
| SCHEMBL1871164 | 0.80 | ADORA1 (0.45) | ADORA1ADORA2B | |
| SCHEMBL1868403 | 0.77 | ADORA2B (0.35) | ADORA1ADORA2B | |
| SCHEMBL1887812 | 0.77 | ADORA2B (0.39) | ADORA1ADORA2B | |
| SCHEMBL1868348 | 0.77 | ADORA1 (0.58) | ADORA1MAPTADORA2B | |
| SCHEMBL1866236 | 0.77 | ADORA1 (0.41) | ADORA1MAPTALDH1A1ADORA2B | |
| SCHEMBL1869565 | 0.76 | ADORA2A (0.40) | ADORA1ADORA2B | |
| SCHEMBL1871541 | 0.76 | HTT (0.44) | ADORA1KDM4EALDH1A1 | |
| SCHEMBL1871663 | 0.76 | TP53 (0.45) | ADORA1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | claimed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | claimed |
| EP-2499142-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | Advinus Therapeutics Limited (IN) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011055391-A1 | SUBSTITUTED FUSED PYRIMIDINE COMPOUNDS, ITS PREPARATION AND USES THEREOF | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2011-05-12 | — | — | WO | disclosed |