Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18681073 | 0.86 | PIK3CA (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGPREP | |
| SCHEMBL23394685 | 0.86 | PREP (0.37) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL18681135 | 0.81 | PREP (0.38) | PIK3CAPIK3CBPIK3CDPIK3CGPREP | |
| SCHEMBL18771926 | 0.77 | PREP (0.32) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL20629567 | 0.77 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL883412 | 0.76 | ELANE (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL18771568 | 0.76 | DPP4 (0.31) | PREPFAPALDH1A1DPP4 | |
| SCHEMBL18681072 | 0.76 | PREP (0.45) | PIK3CAPREPFAPKDM4E | |
| SCHEMBL18681357 | 0.75 | PREP (0.41) | PREPFAPKDM4ESIGMAR1 | |
| SCHEMBL18675245 | 0.75 | FAP (0.51) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170088582-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS, INC. (US) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088582-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | PIK3CA 2982/4885PIK3CB 1680/4885PIK3CD 3033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.