Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216264 | 0.65 | HSD17B10 (0.48) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL4720099 | 0.63 | TDP1 (0.39) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL22728572 | 0.61 | HSD17B10 (0.49) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL29732359 | 0.61 | HSD17B10 (0.49) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| Bromide SCHEMBL28205273 | 0.61 | HSD17B10 (0.41) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL9643856 | 0.61 | HTR1A (0.74) | ALDH1A1HSD17B10HPGDHTR3EHTR3B | |
| SCHEMBL3517237 | 0.60 | HSD17B10 (0.47) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL8990319 | 0.60 | POLB (0.63) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL30285929 | 0.60 | POLB (0.63) | ALDH1A1MAPTHSD17B10HPGDPKM | |
| SCHEMBL18770820 | 0.60 | POLB (0.63) | ALDH1A1MAPTHSD17B10HPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493852-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | Janssen Pharmaceutica NV (BE) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011053706-A1 | 4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-05-05 | — | — | WO | disclosed |