Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.41 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.41 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4216264 | 0.85 | HSD17B10 (0.48) | HSD17B10HTR3EHTR3BCYP1A2HTR1A | |
| SCHEMBL26026421 | 0.78 | PRKDC (0.36) | CYP1A2TSHRALDH1A1KDM4EMAPT | |
| Bromide SCHEMBL17766639 | 0.75 | DPP4 (0.41) | CYP1A2CYP2D6ALDH1A1KDM4EHPGD | |
| Bromide SCHEMBL17766599 | 0.75 | DPP4 (0.41) | CYP1A2CYP2D6ALDH1A1KDM4EHPGD | |
| SCHEMBL25635217 | 0.74 | PRKDC (0.34) | ALDH1A1KDM4EMAPTHPGDGAA | |
| SCHEMBL16728719 | 0.74 | SMN1; SMN2 (0.42) | TSHRALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL16098365 | 0.73 | DPP4 (0.42) | CYP1A2CYP2D6ALDH1A1KDM4EHPGD | |
| SCHEMBL16098079 | 0.73 | DPP4 (0.42) | CYP1A2CYP2D6ALDH1A1KDM4EHPGD | |
| SCHEMBL12349444 | 0.73 | ALOX5 (0.38) | HSD17B10TSHRALDH1A1KDM4EMAPT | |
| Iodide SCHEMBL11901430 | 0.73 | MAOA (0.34) | HSD17B10NFKB1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107743502-A | Solidification composition filling | 爱客多有限公司 | 2018-02-27 | — | — | CN | claimed |
| CN-107743502-B | Curing composition | 爱客多有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-107743502-A | Solidification composition filling | 爱客多有限公司 | 2018-02-27 | — | — | CN | disclosed |