SCHEMBL18680446

SCHEMBL18680446

C[Si]1(C)c2ccccc2N(c2nc3cc4oc(-c5ccccc5)nc4cc3o2)c2ccccc21

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 10/20 0.50
NPC1 O15118 10/20 0.50
RAB9A P51151 10/20 0.50
KDM4E B2RXH2 9/20 0.50
HPGD P15428 6/20 0.50
CASP3 P42574 3/20 0.50
SENP7 Q9BQF6 3/20 0.50
SENP6 Q9GZR1 3/20 0.50
POLB P06746 2/20 0.50
SENP8 Q96LD8 2/20 0.50
ALDH1A1 P00352 9/20 0.40
MAPT P10636 5/20 0.40
TP53 P04637 3/20 0.40
HSD17B10 Q99714 3/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
NFKB1 P19838 3/20 0.39
NFKB2 Q00653 3/20 0.39
RELA Q04206 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17283259 0.91 CASP3 (0.35) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283302 0.88 SMN1; SMN2 (0.45) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283344 0.88 SMN1; SMN2 (0.47) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283240 0.86 NPC1 (0.45) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283333 0.83 SMN1; SMN2 (0.50) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17404429 0.82 NPC1 (0.44) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283336 0.82 SMN1; SMN2 (0.52) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283345 0.81 NPC1 (0.52) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283330 0.81 SMN1; SMN2 (0.49) SMN1; SMN2NPC1RAB9AKDM4EHPGD
SCHEMBL17283343 0.81 SMN1; SMN2 (0.48) SMN1; SMN2NPC1RAB9AKDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230380277-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency UDC IRELAND LTD (IE) 2023-11-23 US disclosed
US-20230380277-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency UDC IRELAND LTD (IE) 2023-11-23 US disclosed
US-11706978-B2 Fluorescent organic light emitting elements having high efficiency UDC IRELAND LIMITED (IE) 2023-07-18 US disclosed
US-11706978-B2 Fluorescent organic light emitting elements having high efficiency UDC IRELAND LIMITED (IE) 2023-07-18 US disclosed
US-20200259100-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency UDC IRELAND LTD (IE) 2020-08-13 US disclosed
US-20170092874-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency BASF SE (DE) 2017-03-30 US disclosed
US-20170092874-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency BASF SE (DE) 2017-03-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230380277-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency TEAD1, TEAD2, TEAD4 SMN1; SMN2 2504/4885NPC1 2870/4885RAB9A 1728/4885
US-11706978-B2 Fluorescent organic light emitting elements having high efficiency TEAD1, TEAD2, TEAD4 SMN1; SMN2 2504/4885NPC1 2870/4885RAB9A 1728/4885
US-20170092874-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency TEAD1, TEAD2, TEAD4 SMN1; SMN2 2504/4885NPC1 2870/4885RAB9A 1728/4885
US-20200259100-A1 Fluorescent Organic Light Emitting Elements Having High Efficiency TEAD1, TEAD2, TEAD4 SMN1; SMN2 2504/4885NPC1 2870/4885RAB9A 1728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.