Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 6/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | VHL | P40337 | 2/20 | 0.32 |
| ▸ | ELOC | Q15369 | 2/20 | 0.32 |
| ▸ | ELOB | Q15370 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18681034 | 1.00 | ATM (0.40) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL18675241 | 0.87 | ATM (0.44) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL18675242 | 0.87 | ATM (0.44) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL18681242 | 0.87 | RIPK1 (0.38) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL17282614 | 0.86 | PIN1 (0.46) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL17282586 | 0.86 | PIN1 (0.46) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL18681117 | 0.85 | PIN1 (0.52) | DPP4DPP8DPP9PIK3CDPIN1 | |
| SCHEMBL18681135 | 0.78 | PREP (0.38) | DPP4DPP8DPP9PIK3CDPIK3CA | |
| SCHEMBL24262637 | 0.77 | DPP4 (0.39) | ATMDPP4DPP8DPP9PIK3CD | |
| SCHEMBL22790711 | 0.77 | VHL (0.44) | ATMDPP4DPP8DPP9PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392422-B2 | Macrocyclic broad spectrum antibiotics | RQX PHARMACEUTICALS, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-10351595-B2 | — | — | 2019-07-16 | — | — | US | disclosed |
| US-20170088582-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS, INC. (US) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10351595-B2 | — | MRPL21, PRSS1, PEPD | ATM 3791/4885DPP4 75/4885DPP8 72/4885 |
| US-10392422-B2 | Macrocyclic broad spectrum antibiotics | MRPL21, PEPD, CTSC | ATM 2604/4885DPP4 58/4885DPP8 62/4885 |
| US-20170088582-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | ATM 2604/4885DPP4 58/4885DPP8 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.