Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.54 |
| ▸ | TDO2 | P48775 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 2/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15338275 | 1.00 | IDO1 (0.54) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| SCHEMBL686394 | 1.00 | IDO1 (0.54) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL11329287 | 0.98 | IDO1 (0.52) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| SCHEMBL153358 | 0.89 | ADRB2 (0.62) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| Ammonia Solution, Strong SCHEMBL7978172 | 0.87 | ADRB2 (0.59) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| SCHEMBL8643448 | 0.87 | ESR1 (0.55) | ADRA2ATSHRCYP2D6ESR1PDCD1 | |
| Methylamine SCHEMBL6499701 | 0.84 | ADRB2 (0.64) | IDO1TDO2ADRB2SLC6A2SLC6A4 | |
| SCHEMBL3818819 | 0.84 | ESR1 (0.48) | ADRA2ACYP2D6ESR1PDCD1ESR2 | |
| SCHEMBL169730 | 0.84 | TAAR1 (0.50) | ADRA2ATSHRCYP2D6ESR1PDCD1 | |
| SCHEMBL7499823 | 0.84 | TAAR1 (0.50) | ADRA2ATSHRCYP2D6ESR1PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9694002-B2 | Substituted benzamides and methods of use thereof | GENENTECH, INC. (US) | 2017-07-04 | — | — | US | disclosed |
| US-20170087136-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170087136-A1 | SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | C1R, SRR, PNISR | IDO1 2555/4885TDO2 3618/4885ADRB2 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.