Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28256635 | 0.78 | TDP1 (0.53) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL2475315 | 0.75 | GAA (0.66) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL11223006 | 0.75 | TDP1 (0.53) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL28294148 | 0.75 | TDP1 (0.53) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL28296005 | 0.75 | TDP1 (0.53) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL19578647 | 0.74 | ALDH1A1 (0.43) | TDP1GAAALDH1A1GPR35NOS1 | |
| SCHEMBL28910275 | 0.72 | TDP1 (0.50) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL23926472 | 0.71 | TDP1 (0.48) | TDP1GAAALDH1A1GPR35HSP90AA1 | |
| SCHEMBL12896239 | 0.71 | GAA (0.49) | TDP1GAAALDH1A1GPR35POLB | |
| SCHEMBL17422039 | 0.71 | TDP1 (0.48) | TDP1GAAALDH1A1GPR35POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-B1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2017-03-29 | — | — | EP | disclosed |