Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1994140 | 0.78 | DRD2 (0.43) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL8546338 | 0.78 | MAPK14 (0.43) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL30390986 | 0.78 | L3MBTL1 (0.56) | L3MBTL1MAPTSMN1; SMN2DRD2DRD4 | |
| SCHEMBL3909627 | 0.78 | DRD2 (0.43) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL4345200 | 0.77 | NPC1 (1.00) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL29415608 | 0.76 | DRD4 (0.63) | L3MBTL1MAPTDRD2DRD4DRD3 | |
| SCHEMBL746079 | 0.76 | DRD4 (0.63) | L3MBTL1MAPTDRD2DRD4DRD3 | |
| SCHEMBL3897534 | 0.76 | POLB (0.43) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL1400228 | 0.76 | PPARD (0.44) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3923636 | 0.75 | MAPT (0.66) | NPC1RAB9AL3MBTL1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855456-B1 | COMPLEMENT PATHWAY MODULATORS AND USES THEREOF | NOVARTIS AG (CH) | 2017-03-29 | — | — | EP | disclosed |