Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275948 | 0.83 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1KMT2AALDH1A1TDP1 | |
| SCHEMBL1872249 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1KMT2AALDH1A1TDP1 | |
| SCHEMBL1872051 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ATDP1BLM | |
| SCHEMBL29896219 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1KMT2ATDP1BLM | |
| SCHEMBL9275943 | 0.76 | CA1 (0.39) | SMN1; SMN2L3MBTL1KMT2AALDH1A1PTGS2 | |
| Trifluoromethanesulfonic Acid SCHEMBL28203196 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1ALDH1A1TDP1TSHR | |
| SCHEMBL9281347 | 0.74 | FDPS (0.45) | SMN1; SMN2L3MBTL1KMT2AALDH1A1TDP1 | |
| SCHEMBL7742363 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1KMT2ATDP1BLM | |
| Butane SCHEMBL27983929 | 0.73 | TDP1 (0.45) | SMN1; SMN2L3MBTL1ALDH1A1TDP1PTGS2 | |
| Trifluoromethanesulfonic Acid SCHEMBL6282631 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496087-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | Diakron Pharmaceuticals, Inc. (US) | 2012-09-12 | — | — | EP | claimed |
| WO-2011056806-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | DIAKRON PHARMACEUTICALS, INC. (US) | 2011-05-12 | — | — | WO | claimed |
| US-20110105753-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | DIAKRON PHARMACEUTICALS, INC. (US) | 2011-05-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105753-A1 | PROCESS FOR THE PREPARATION OF PYRAZINONE THROMBIN INHIBITOR AND ITS INTERMEDIATES | TFPI, TFPI2, F2 | SMN1; SMN2 4456/4885L3MBTL1 4752/4885KMT2A 2539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.