Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoromethanesulfonic Acid SCHEMBL28203196 | 0.86 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| SCHEMBL29080 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| SCHEMBL29349628 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| Trifluoromethanesulfonic Acid SCHEMBL7149550 | 0.80 | PGK1 (0.44) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EABCC9 | |
| SCHEMBL18263711 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1ALDH1A1KDM4ENPC1 | |
| Ammonia Solution, Strong SCHEMBL7412270 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| SCHEMBL29016490 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| Iodide SCHEMBL2177798 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| SCHEMBL29798224 | 0.79 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR | |
| SCHEMBL6652864 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1ALDH1A1KDM4EAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974870-B2 | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses | BOEHRINGER INGELHEIM PHAMACEUTICALS, INC. (US) | 2005-12-13 | — | — | US | disclosed |
| US-20040180922-A1 | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180922-A1 | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses | NFKBIA, IKBKB, CHUK | SMN1; SMN2 3870/4885L3MBTL1 3632/4885ALDH1A1 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.