Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.32 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.32 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18685454 | 1.00 | TDP2 (0.36) | TDP2AAK1PSMB8PSMB9PSMB5 | |
| SCHEMBL18685287 | 1.00 | TDP2 (0.36) | TDP2AAK1PSMB8PSMB9PSMB5 | |
| SCHEMBL26067137 | 0.72 | TDP2 (0.42) | TDP2 | |
| SCHEMBL20320448 | 0.67 | TDP2 (0.49) | TDP2 | |
| SCHEMBL16232148 | 0.59 | AAK1 (0.37) | AAK1 | |
| SCHEMBL16232145 | 0.59 | AAK1 (0.37) | AAK1 | |
| SCHEMBL4470815 | 0.58 | TDP2 (0.46) | TDP2 | |
| SCHEMBL20320451 | 0.58 | TDP2 (0.50) | TDP2 | |
| SCHEMBL23686272 | 0.58 | AAK1 (0.33) | AAK1 | |
| SCHEMBL31546906 | 0.57 | TDP2 (0.45) | TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914702-B2 | Amine derivatives as potassium channel blockers | BIONOMICS LIMITED (AU) | 2018-03-13 | — | — | US | disclosed |
| US-20170088519-A1 | AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS | BIONOMICS, LTD (AU) | 2017-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170088519-A1 | AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS | KCNA3, KCNH3, KCNK3 | TDP2 1993/4885AAK1 1517/4885PSMB8 2013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.