Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 4/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.39 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822276 | 0.80 | MAPK10 (0.36) | MAPK10KDM4ESCN1ASCN5ASCN8A | |
| SCHEMBL461146 | 0.73 | KMT2A (0.48) | AURKAMAPTMEN1KMT2AKDM4E | |
| SCHEMBL7341519 | 0.72 | MAPK10 (0.73) | MAPK10AURKAMAPTMEN1KMT2A | |
| SCHEMBL29796528 | 0.72 | MAPK10 (0.73) | MAPK10AURKAMAPTMEN1KMT2A | |
| SCHEMBL1518965 | 0.71 | MAPK10 (1.00) | MAPK10AURKAMAPTMEN1KMT2A | |
| SCHEMBL29793294 | 0.71 | CXCL8 (0.55) | MAPK10AURKAMAPTMEN1KMT2A | |
| SCHEMBL396120 | 0.71 | CXCL8 (0.55) | MAPK10AURKAMAPTMEN1KMT2A | |
| SCHEMBL20751634 | 0.69 | NPC1 (0.42) | MEN1KMT2AKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL1093291 | 0.69 | SCN1A (0.55) | SCN1ASCN5ASCN8ASCN1BNR1I2 | |
| SCHEMBL3951907 | 0.67 | AURKA (0.56) | MAPK10AURKAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |