SCHEMBL461146

SCHEMBL461146

c1ccc(Nc2cscn2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.48
MAPT P10636 5/20 0.48
MEN1 O00255 5/20 0.48
RAB9A P51151 4/20 0.48
TDP1 Q9NUW8 2/20 0.48
KDM4E B2RXH2 1/20 0.48
ALPG P10696 1/20 0.48
MAPK1 P28482 2/20 0.44
CDK2 P24941 2/20 0.44
CSNK2A1 P68400 2/20 0.44
PLK3 Q9H4B4 2/20 0.44
PDGFRB P09619 2/20 0.44
PDGFRA P16234 2/20 0.44
NPC1 O15118 2/20 0.44
CHEK1 O14757 1/20 0.44
IKBKB O14920 1/20 0.44
AURKA O14965 1/20 0.44
PDPK1 O15530 1/20 0.44
CHEK2 O96017 1/20 0.44
PRKCG P05129 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8842706 0.78 TNNI3K (0.44) AURKA
SCHEMBL5898450 0.74 ALDH1A1 (0.57) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL1868593 0.73 MAPK10 (0.56) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL3822276 0.69 MAPK10 (0.36) KDM4E
SCHEMBL1093964 0.68 SCN1A (0.54) KMT2AMEN1KDM4EHSD17B10ALDH1A1
SCHEMBL29582475 0.67 MEN1 (0.64) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL414719 0.67 MEN1 (0.70) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL626575 0.67 MEN1 (0.64) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL2840428 0.67 KMT2A (0.48) KMT2AMAPTMEN1RAB9ATDP1
SCHEMBL3759875 0.66 MAPT (1.00) KMT2AMAPTMEN1RAB9ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0006368-B1 4-PHENYL-THIAZOLYL-2-OXAMATE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF ASTHMA PIERRE FABRE S.A. (FR) 1981-11-18 EP claimed
US-20150307571-A1 Stresscopins and their Uses THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2015-10-29 US disclosed
US-20150025125-A1 Stresscopins and their Uses THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY 2015-01-22 US disclosed
CN-101528704-B Serine-threonine protein kinase and PARP modulators CYLENE PHARMACEUTICALS INC 2014-04-09 CN disclosed
US-8481686-B2 Antibodies that bind stresscopin peptides THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2013-07-09 US disclosed
EP-2498608-A1 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS GlaxoSmithKline LLC (US) 2012-09-19 EP disclosed
US-20120066775-A1 Stresscopins and their Uses THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2012-03-15 US disclosed
WO-2011059610-A1 BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2011-05-19 WO disclosed
CN-102036561-A Protein kinase modulators CYLENE PHARMACEUTICALS INC 2011-04-27 CN disclosed
US-7829330-B2 Stresscopins and their uses THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2010-11-09 US disclosed
WO-2002034934-A2 STRESSCOPINS AND THEIR USES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2002-05-02 WO disclosed
US-6348477-B1 SUBSTITUTED PHENYL THIAZOLE DERIVATIVES AS VIRICIDES BOEHRINGER INGELHEIM(CANADA) LTD. (CA) 2002-02-19 US disclosed
US-6288091-B1 COMPOUNDS SUCH AS 2,2,2-TRICHLOROETHYL N-(4-(2-AMINO-4-THIAZOLYL)-PHENYL)CARBAMATE THAT INHIBIT THE HERPES HELCASE-PRIMASE ENZYME COMPLEX BOEHRINGER INGELHEIM LTD. (CA) 2001-09-11 US disclosed
WO-2000029399-A1 ANTIHERPES COMPOUNDS BOEHRINGER INGELHEIM (CANADA) LTD. (CA) 2000-05-25 WO disclosed
US-6057451-A AMINOTHIAZOLE DERIVATIVES BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-05-02 US disclosed
US-5880135-A ANTAGONIST ACTIVITY WITH RESPECT TO CORTICOTROPIN RELEASING HORMONE SANOFI (FR) 1999-03-09 US disclosed
EP-0871619-A1 PHENYL THIAZOLE DERIVATIVES WITH ANTI HERPES VIRUS PROPERTIES BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 1998-10-21 EP disclosed
CN-1188476-A 4-phenylaminothiazole derivatives, method for preparing same, and pharmaceutical compositions thereof SANOFI SA (FR) 1998-07-22 CN disclosed
CN-1188476-A 4-phenylaminothiazole derivatives, method for preparing same, and pharmaceutical compositions thereof SANOFI SA (FR) 1998-07-22 CN disclosed
WO-1997024343-A1 PHENYL THIAZOLE DERIVATIVES WITH ANTI HERPES VIRUS PROPERTIES BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 1997-07-10 WO disclosed