Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 15/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 15/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 14/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SCN1B | Q07699 | 3/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1868593 | 0.80 | MAPK10 (0.56) | MAPK10SCN1ASCN8ASCN5AKDM4E | |
| SCHEMBL3944985 | 0.72 | KDM4E (0.35) | MAPK10KDM4ESLC40A1 | |
| SCHEMBL14048610 | 0.69 | MEN1 (0.65) | KDM4ECYP2C9 | |
| SCHEMBL461146 | 0.69 | KMT2A (0.48) | KDM4E | |
| SCHEMBL25167315 | 0.67 | ADRA2A (0.56) | KDM4E | |
| SCHEMBL5006940 | 0.66 | MAPT (0.50) | KDM4E | |
| Hydrochloric Acid SCHEMBL4594657 | 0.65 | MAPT (0.48) | KDM4E | |
| SCHEMBL6625263 | 0.64 | TDP1 (0.38) | KDM4ECYP2C9SLC40A1 | |
| SCHEMBL8852094 | 0.64 | IDO1 (0.57) | KDM4ESLC40A1 | |
| SCHEMBL30366540 | 0.64 | HPRT1 (0.46) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089355-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF- KAPPA B ACTIVITY AND USE THEREOF | Brystol-Myers Squibb Company (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008057862-A2 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |