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SCHEMBL18686342

SCHEMBL18686342

CS(=O)(=O)N(CC1CCN(C(=O)OC(C(F)(F)F)C(F)(F)F)CC1)c1ccc(Cl)cc1

nearest known ligand 0.61

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MGLL Q99685 12/20 0.61
▸ ABHD6 Q9BV23 7/20 0.52
▸ PLA2G7 Q13093 4/20 0.52
▸ TACR1 P25103 1/20 0.42
▸ MC4R P32245 2/20 0.42
▸ GPR119 Q8TDV5 1/20 0.42
▸ ALDH1A1 P00352 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27900142 0.81 TACR1 (0.47) TACR1MC4RALDH1A1L3MBTL1
SCHEMBL28001461 0.78 MGLL (0.57) MGLLABHD6PLA2G7
SCHEMBL15050684 0.76 MGLL (0.67) MGLLABHD6PLA2G7
SCHEMBL14834237 0.76 MGLL (1.00) MGLLABHD6PLA2G7ALDH1A1
SCHEMBL14834372 0.75 MGLL (0.76) MGLLABHD6PLA2G7
SCHEMBL14834107 0.74 MGLL (0.46) MGLLABHD6PLA2G7GPR119
SCHEMBL14834226 0.74 MGLL (0.46) MGLLABHD6PLA2G7GPR119
SCHEMBL14834300 0.73 MGLL (0.62) MGLLABHD6PLA2G7
SCHEMBL14834481 0.73 MGLL (0.68) MGLLABHD6PLA2G7ALDH1A1
SCHEMBL14834295 0.73 MGLL (0.79) MGLLABHD6PLA2G7ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2576507-B1 HEXAFLUOROISOPROPYL CARBAMATE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION SANOFI SA (FR) 2017-04-05 — — EP disclosed