Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15637367 | 0.80 | MAPT (0.48) | GPR119MAPTNPSR1ATMUSP30 | |
| SCHEMBL15636742 | 0.79 | SLC6A4 (0.47) | KDM5BKDM5AKDM5CKDM4CPIK3CA | |
| SCHEMBL15637003 | 0.79 | UBE2M (0.42) | — | |
| SCHEMBL15635959 | 0.77 | MAPT (0.49) | MAPTNPSR1ATMUSP30KDM5B | |
| SCHEMBL15635957 | 0.77 | MAPT (0.49) | MAPTNPSR1ATMUSP30KDM5B | |
| SCHEMBL15637263 | 0.74 | KDM5B (0.44) | MAPTKDM5BMEN1KMT2AKDM5A | |
| SCHEMBL15637130 | 0.72 | PIK3CA (0.42) | MAPTNPSR1KDM5BKDM5AKDM5C | |
| Dihydrocinnamaldehyde SCHEMBL15636710 | 0.70 | SLC6A4 (0.42) | KDM5BKDM5AKDM5CKDM4C | |
| SCHEMBL24220741 | 0.70 | ALDH1A1 (0.42) | GPR119MAPTUSP30MEN1KMT2A | |
| SCHEMBL20951269 | 0.69 | PIK3CA (0.65) | GPR119MAPTATMPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107434803-B | Inhibitors of histone demethylases | 吉利德科学公司 | 2020-05-05 | — | — | CN | disclosed |
| US-10221139-B2 | Inhibitors of histone demethylases | GILEAD SCIENCES, INC. (US) | 2019-03-05 | — | — | US | disclosed |
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10221139-B2 | Inhibitors of histone demethylases | EHMT1, KDM1B, EHMT2 | GPR119 1435/4885MAPT 3027/4885NPSR1 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.