Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TEC | P42680 | 4/20 | 0.39 |
| ▸ | TXK | P42681 | 3/20 | 0.39 |
| ▸ | ITK | Q08881 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21725695 | 0.87 | ACSS2 (0.39) | ACSS2BRD4TLR7ATMTEC | |
| SCHEMBL16767956 | 0.87 | EGFR (0.45) | ACSS2BRD4TLR7ATMNPC1 | |
| SCHEMBL18687362 | 0.87 | TEC (0.54) | ACSS2BRD4TLR7ATMTEC | |
| SCHEMBL16755394 | 0.85 | THRB (0.43) | ACSS2BRD4ATMNPC1KDM4E | |
| SCHEMBL18687358 | 0.84 | SIRT2 (0.46) | ACSS2BRD4TLR7ATMNPC1 | |
| SCHEMBL18687505 | 0.82 | TXK (0.52) | ACSS2TECTXKITK | |
| SCHEMBL18687403 | 0.82 | NPC1 (0.39) | ATMTECTXKITKNPC1 | |
| SCHEMBL18688109 | 0.81 | TEC (0.62) | TECTXKITK | |
| SCHEMBL18687523 | 0.81 | ATM (0.41) | ACSS2BRD4ATMNPC1KDM4E | |
| SCHEMBL18687394 | 0.80 | ITK (0.47) | ACSS2BRD4ATMTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017049401-A1 | NEW BENZIMIDAZOLES DERIVATIVES AS TEC KINASES FAMILY INHIBITORS | PHARMASCIENCE INC. (CA) | 2017-03-30 | — | — | WO | disclosed |