Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18691779 | 0.87 | LMNA (0.62) | LMNAALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18691792 | 0.85 | HDAC6 (0.56) | LMNAALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18691777 | 0.80 | HDAC6 (0.66) | LMNAALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL18691786 | 0.76 | LMNA (0.60) | LMNAALOX15ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL10469111 | 0.73 | TNF (0.55) | LMNAALOX15TNF | |
| SCHEMBL20477208 | 0.72 | CYP4F2 (0.48) | LMNAALDH1A1KDM4EHSD17B10TOP2A | |
| SCHEMBL941980 | 0.72 | CYP4F2 (0.49) | LMNATNFPDE4DTOP2AMAPT | |
| SCHEMBL14578725 | 0.71 | TNF (0.61) | LMNATNFCNR2 | |
| SCHEMBL14358207 | 0.69 | CYP1A2 (0.50) | LMNAALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL29328629 | 0.68 | GAA (0.46) | LMNATNFALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |