Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18691782 | 0.87 | LMNA (0.56) | LMNAALOX15ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL18691786 | 0.81 | LMNA (0.60) | LMNAALOX15ALDH1A1KDM4EMEN1 | |
| SCHEMBL18691794 | 0.80 | ALDH1A1 (0.50) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18691777 | 0.77 | HDAC6 (0.66) | LMNAALOX15ALDH1A1KDM4EMEN1 | |
| SCHEMBL18691792 | 0.75 | HDAC6 (0.56) | LMNAALOX15ALDH1A1KDM4EMEN1 | |
| SCHEMBL14358207 | 0.73 | CYP1A2 (0.50) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6344652 | 0.72 | MAPT (0.54) | LMNAALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL18691781 | 0.72 | ALDH1A1 (0.52) | LMNAALOX15ALDH1A1KDM4EMEN1 | |
| SCHEMBL7010780 | 0.71 | MAPT (0.53) | LMNAALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL1989725 | 0.71 | ALDH1A1 (0.46) | LMNAALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |