Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3008954 | 0.83 | CSF1R (0.63) | SMN1; SMN2ALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL18691779 | 0.81 | LMNA (0.62) | LMNASMN1; SMN2ALDH1A1MAPK1MAPT | |
| SCHEMBL18691781 | 0.81 | ALDH1A1 (0.52) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL11392754 | 0.80 | CSF1R (0.55) | KMT2ATSHRPOLBCSF1RMEN1 | |
| SCHEMBL2783058 | 0.80 | OGFRL1 (0.56) | ALDH1A1MAPK1MAPTTSHRHSD17B10 | |
| SCHEMBL18691776 | 0.80 | ALDH1A1 (0.48) | LMNAALDH1A1MAPTKMT2AALOX15 | |
| SCHEMBL18691772 | 0.80 | ADORA3 (0.49) | LMNAALDH1A1KMT2ATSHRBRD4 | |
| SCHEMBL2782278 | 0.79 | CSF1R (0.54) | LMNASMN1; SMN2ALDH1A1MAPK1MAPT | |
| SCHEMBL2783043 | 0.77 | PDE4B (0.56) | LMNAKMT2ATSHRPOLBCSF1R | |
| SCHEMBL1372818 | 0.77 | AHR (0.55) | LMNAALDH1A1KMT2ATSHRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |