Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10897013 | 0.85 | MMP8 (0.44) | CA1CA2CA12CA7CA14 | |
| SCHEMBL1446470 | 0.82 | RELA (0.46) | CA1CA2CA12CA7CA14 | |
| SCHEMBL2010127 | 0.80 | CA1 (0.44) | CA1CA2CA12CA7CA14 | |
| SCHEMBL1110883 | 0.79 | RELA (0.44) | RELAALDH1A1HSD17B10PPARA | |
| SCHEMBL608990 | 0.78 | CA1 (0.61) | CA1CA2CA12CA7CA14 | |
| SCHEMBL5689488 | 0.78 | CA1 (0.52) | CA1CA2CA12CA7CA14 | |
| SCHEMBL14173629 | 0.77 | RELA (0.46) | RELAALDH1A1HSD17B10PPARAFAAH | |
| SCHEMBL11521699 | 0.77 | RELA (0.46) | RELAALDH1A1HSD17B10PPARAFAAH | |
| SCHEMBL5604517 | 0.77 | RELA (0.46) | RELAALDH1A1HSD17B10PPARAFAAH | |
| SCHEMBL10559242 | 0.77 | RELA (0.46) | RELAALDH1A1HSD17B10PPARAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2496575-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES USEFUL AS MEK INHIBITORS | Novartis AG (CH) | 2012-09-12 | — | — | EP | disclosed |
| WO-2011054828-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES USEFUL AS MEK INHIBITORS | NOVARTIS AG (CH) | 2011-05-12 | — | — | WO | disclosed |