Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 9/20 | 0.43 |
| ▸ | EGFR | P00533 | 6/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308326 | 0.92 | SIRT1 (0.45) | GAAGFERSIRT1 | |
| SCHEMBL16197120 | 0.88 | SCN9A (0.50) | BTKSRC | |
| SCHEMBL18700190 | 0.87 | BTK (0.49) | LTA4HCHEK2BTKEGFR | |
| SCHEMBL18700125 | 0.85 | BTK (0.50) | CHEK2BTKGAAGFER | |
| SCHEMBL18700210 | 0.82 | CHEK2 (0.48) | CHEK2MEN1KMT2ABTKGAA | |
| SCHEMBL29709430 | 0.81 | LCK (0.45) | BTKGAAGFER | |
| SCHEMBL18700213 | 0.80 | SCN9A (0.53) | CHEK2BTKEGFRSRC | |
| SCHEMBL25891793 | 0.79 | GAA (0.43) | MEN1KMT2ABTKGAAGFER | |
| SCHEMBL11144994 | 0.78 | MAP2K4 (0.52) | KMT2ARAB9A | |
| SCHEMBL19636003 | 0.77 | SCN4A (0.54) | BTKEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914586-B1 | BRUTON'S TYROSINE KINASE INHIBITORS | PFIZER (US) | 2017-04-05 | — | — | EP | disclosed |