Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BTK | Q06187 | 9/20 | 0.46 |
| ▸ | GFER | P55789 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.38 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16197120 | 0.83 | SCN9A (0.50) | BTKLCK | |
| SCHEMBL18700175 | 0.82 | LTA4H (0.48) | CHEK2KMT2AMEN1BTKGFER | |
| SCHEMBL18700125 | 0.81 | BTK (0.50) | CHEK2SMN1; SMN2BTKGFERLMNA | |
| SCHEMBL29709430 | 0.80 | LCK (0.45) | BTKGFERGAALCK | |
| SCHEMBL25892423 | 0.77 | ALDH1A1 (0.44) | MAPTSMN1; SMN2GFERLMNAGAA | |
| SCHEMBL25891793 | 0.75 | GAA (0.43) | KMT2AMEN1BTKGFERGAA | |
| SCHEMBL19636003 | 0.75 | SCN4A (0.54) | BTK | |
| SCHEMBL16247149 | 0.75 | SRC (0.58) | SMN1; SMN2BTKGFERGAA | |
| SCHEMBL17637853 | 0.74 | MAP2K4 (0.47) | GFERLMNAGAAMAPK1MAP2K4 | |
| SCHEMBL18700213 | 0.74 | SCN9A (0.53) | CHEK2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2914586-B1 | BRUTON'S TYROSINE KINASE INHIBITORS | PFIZER (US) | 2017-04-05 | — | — | EP | disclosed |