⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8717623 | 0.78 | — | — | |
| SCHEMBL28818310 | 0.76 | TDP1 (0.31) | — | |
| SCHEMBL105204 | 0.73 | CA1 (0.48) | — | |
| SCHEMBL160506 | 0.73 | — | — | |
| SCHEMBL19917 | 0.71 | — | — | |
| SCHEMBL21590 | 0.71 | — | — | |
| SCHEMBL340606 | 0.71 | — | — | |
| SCHEMBL194173 | 0.71 | — | — | |
| SCHEMBL161096 | 0.71 | — | — | |
| SCHEMBL28053489 | 0.71 | CA1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984734-B1 | SIGMA-2 RECEPTOR, METHOD OF SCREENING OF SPECIFIC LIGANDS AND USE OF THE SAME IN DIAGNOSTIC OR THERAPEUTIC METHODS | UNIV BARI (IT) | 2014-05-07 | — | — | EP | claimed |
| US-20090017038-A1 | Sigma-2 Receptor, Method of Screening of Specific Ligands and Use of the Same in Diagnostic or Therapeutic Methods | UNIVERSITA DEGLI STUDI DI BARI (IT) | 2009-01-15 | — | — | US | claimed |
| EP-1984734-A2 | SIGMA-2 RECEPTOR, METHOD OF SCREENING OF SPECIFIC LIGANDS AND USE OF THE SAME IN DIAGNOSTIC OR THERAPEUTIC METHODS | Universita' degli studi di Bari (IT) | 2008-10-29 | — | — | EP | claimed |
| WO-2008073451-A2 | BENZOIMIDAZOLE DERIVATIVES AS SIRTUIN (SIR) MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2007077543-A2 | SIGMA-2 RECEPTOR, METHOD OF SCREENING OF SPECIFIC LIGANDS AND USE OF THE SAME IN DIAGNOSTIC OR THERAPEUTIC METHODS | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2007-07-12 | — | — | WO | claimed |
| CN-116425721-B | Bicyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116425721-A | Bicyclic compounds as MAT2A inhibitors | 艾立康药业股份有限公司 | 2023-07-14 | — | — | CN | disclosed |
| CN-113444016-A | Molecules having pesticidal utility, and intermediates, compositions and methods related thereto | 美国陶氏益农公司 | 2021-09-28 | — | — | CN | disclosed |
| CN-107734969-B | Molecules having pesticidal utility, and intermediates, compositions and methods related thereto | 美国陶氏益农公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-110913855-A | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2020-03-24 | — | — | CN | disclosed |
| CN-106458930-B | 2-aminopyrimidine compound and pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2019-10-11 | — | — | CN | disclosed |
| CN-109690317-A | For measuring the composition and method of cell intermediate ion channel activity | 生命科技股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| WO-2008073451-A2 | BENZOIMIDAZOLE DERIVATIVES AS SIRTUIN (SIR) MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| WO-2008016192-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-02-07 | — | — | WO | disclosed |
| US-7094798-B1 | Inhibitors of checkpoint kinases (Wee1 and Chk1) | PFIZER INC (US) | 2006-08-22 | — | — | US | disclosed |
| CN-1190197-C | Application of cyanoquinoline in preparing medicine for treating or inhibiting colonic polyp | HEWLETT HOLDINGS CORP (US) | 2005-02-23 | — | — | CN | disclosed |
| EP-1501831-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091255-A1 | INHIBITORS OF CHECKPOINT KINASES (WEE1 AND CHK1) | WARNER-LAMBERT COMPANY LLC (US) | 2003-11-06 | — | — | WO | disclosed |
| CN-1429126-A | Use of cyanoquinolines for treating or inhibiting colonic polyps | AMERICAN CYANAMID CO (US) | 2003-07-09 | — | — | CN | disclosed |
| US-6540793-B1 | Coupler for use in oxidative hair dyeing | CLAIROL INCORPORATED | 2003-04-01 | — | — | US | disclosed |