⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9111454 | 0.77 | PTPN1 (0.32) | — | |
| SCHEMBL159912 | 0.76 | ADRB2 (0.31) | — | |
| SCHEMBL162984 | 0.76 | NQO1 (0.36) | — | |
| SCHEMBL359290 | 0.76 | HTR2C (0.35) | — | |
| SCHEMBL358869 | 0.74 | KDM4E (0.36) | — | |
| SCHEMBL105204 | 0.73 | CA1 (0.48) | — | |
| SCHEMBL160506 | 0.73 | — | — | |
| SCHEMBL9652575 | 0.73 | MAOA (0.45) | — | |
| SCHEMBL3958751 | 0.73 | TTR (0.36) | — | |
| SCHEMBL24397 | 0.73 | CA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3194 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024120442-A1 | PAK4 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CONVERGEN (SUZHOU) PHARMACEUTICAL CO., LTD. (CN) | 2024-06-13 | — | — | WO | claimed |
| US-11987588-B2 | Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2024-05-21 | — | — | US | claimed |
| CN-118055930-A | Thiadiazole derivative, composition and application thereof | 北京丹擎医药科技有限公司 | 2024-05-17 | — | — | CN | claimed |
| US-20230183248-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-15 | — | — | US | claimed |
| EP-3720858-B1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2023-06-07 | — | — | EP | claimed |
| WO-2023061415-A1 | THIADIAZOLYL DERIVATIVES, COMPOSITIONS AND USES THEREOF | DANATLAS PHARMACEUTICALS CO., LTD. (CN) | 2023-04-20 | — | — | WO | claimed |
| EP-4135842-A1 | PYRROLO[1,2-D][1,2,4]TRIAZINE-2-YL-ACETAMIDES AS INHIBITORS OF THE NLRP3 INFLAMMASOME PATHWAY | JANSSEN Pharmaceutica NV (BE) | 2023-02-22 | — | — | EP | claimed |
| CN-115485026-A | Pyrazolo [1,2-D ] [1,2,4] triazin-2-yl-acetamides as NLRP3 inflammatory pathway inhibitors | 詹森药业有限公司 | 2022-12-16 | — | — | CN | claimed |
| US-20220396579-A1 | MODULATORS OF THE BETA-3 ADRENERGIC RECEPTOR USEFUL FOR THE TREATMENT OR PREVENTION OF HEART FAILURE AND DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2022-12-15 | — | — | US | claimed |
| CN-107879975-B | Histone deacetylase inhibitor and application thereof | 中国科学院上海药物研究所 | 2022-07-26 | — | — | CN | claimed |
| US-4696675-A | Process for preparing water-insoluble blue azo dyes on the fiber: hydroxynaphthoic amide and diazotized di-alkoxy-benzidine | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-09-29 | — | — | US | claimed |
| EP-0199973-A2 | Process for the production on the fibre of water insoluble azo dyes | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-11-05 | — | — | EP | claimed |
| EP-0091193-B1 | ANTIDIABETIC COMPOSITIONS | PFIZER INC. (US) | 1986-05-21 | — | — | EP | claimed |
| EP-0091193-A2 | Antidiabetic compositions | PFIZER INC. (US) | 1983-10-12 | — | — | EP | claimed |
| US-4159983-A | Pure and substantially pure asymmetric 1:2 cobalt complexes of monoazo compounds | SANDOZ LTD. (CH) | 1979-07-03 | — | — | US | claimed |
| US-4051156-A | N-(triaryl-methyl)-amidines, process for the preparation thereof and compositions containing the same | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1977-09-27 | — | — | US | claimed |
| US-4041036-A | NAPHTHO(1',2':5,6)-PYRANO(2,3-D)PYRIMIDINE DYES | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-08-09 | — | — | US | claimed |
| US-4029666-A | Benzenesulfonyl-ureas and process for preparing them | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-06-14 | — | — | US | claimed |
| US-3953449-A | ANALGESICS | SYNTHELABO (FR) | 1976-04-27 | — | — | US | claimed |
| US-3932503-A | Benzenesulfonyl ureas | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-01-13 | — | — | US | claimed |