Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5061024 | 0.76 | GABRA1 (0.52) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL9887839 | 0.74 | TSHR (0.47) | TSHRGABRA1GABRB2POLBLMNA | |
| SCHEMBL467714 | 0.72 | GABRA1 (0.54) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL30509009 | 0.72 | TSHR (0.48) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL11504087 | 0.70 | GABRA1 (0.62) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL30195663 | 0.70 | GABRA1 (0.62) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL7108211 | 0.70 | TSHR (0.50) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL11791480 | 0.69 | GABRA1 (0.54) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL20235587 | 0.68 | GABRA1 (0.48) | TSHRGABRA1GABRB2POLBHPGD | |
| SCHEMBL196228 | 0.68 | GABRA1 (0.59) | TSHRGABRA1GABRB2POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611284-B2 | Prostaglandin-bisphosphonate conjugate compounds, methods of making same, and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2017-04-04 | — | — | US | disclosed |