Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PNP | P00491 | 2/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.34 |
| ▸ | KDM4A | O75164 | 3/20 | 0.34 |
| ▸ | KDM5C | P41229 | 3/20 | 0.34 |
| ▸ | KDM4B | O94953 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | KDM6B | O15054 | 1/20 | 0.30 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15636891 | 0.79 | KDM5B (0.49) | DNM1KDM4EKDM5BKDM4AKDM5C | |
| SCHEMBL16310760 | 0.79 | KDM5B (0.49) | DNM1KDM4EKDM5BKDM4AKDM5C | |
| SCHEMBL18708416 | 0.75 | DNM1 (0.36) | DNM1KDM4EPNPKDM5BPDGFRB | |
| SCHEMBL29955237 | 0.74 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16293002 | 0.74 | KDM5B (0.43) | KDM5BKDM4AKDM5CKDM4BKDM6B | |
| SCHEMBL7103571 | 0.71 | PNP (0.42) | DNM1KDM4EPNPTYMPCD274 | |
| SCHEMBL15994191 | 0.70 | SIRT2 (0.41) | KDM5BKDM4AKDM5CKDM4B | |
| SCHEMBL16293691 | 0.70 | KDM5B (0.43) | KDM5BKDM4AKDM5CKDM6BKDM5A | |
| SCHEMBL16294293 | 0.69 | KDM5B (0.46) | KDM4EKDM5BKDM4AKDM5CKDM4B | |
| SCHEMBL16293697 | 0.69 | KDM5C (0.47) | KDM4EKDM5BKDM4AKDM5CKDM4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150582-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. (US) | 2017-04-05 | — | — | EP | disclosed |