Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.42 |
| ▸ | TYMP | P19971 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | UPP1 | Q16831 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657692 | 0.83 | CD274 (0.46) | PNPDNM1KDM4ECD274PDCD1 | |
| SCHEMBL7105047 | 0.82 | PNP (0.43) | PNPDNM1KDM4E | |
| SCHEMBL7104789 | 0.82 | PNP (0.41) | PNPKDM4E | |
| SCHEMBL7108772 | 0.81 | PNP (0.38) | PNPTYMPDNM1KDM4ECD274 | |
| SCHEMBL7656011 | 0.77 | TRPV3 (0.43) | PNPTYMPDNM1KDM4ECD274 | |
| SCHEMBL7659608 | 0.73 | PNP (0.38) | PNPTYMPDNM1CD274PDCD1 | |
| SCHEMBL27756229 | 0.73 | TYMP (0.40) | PNPTYMPDNM1KDM4ECD274 | |
| SCHEMBL27777044 | 0.73 | TYMP (0.40) | PNPTYMPDNM1KDM4ECD274 | |
| SCHEMBL27756230 | 0.73 | TYMP (0.40) | PNPTYMPDNM1KDM4ECD274 | |
| SCHEMBL18708126 | 0.71 | DNM1 (0.38) | PNPTYMPDNM1KDM4ECD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |