Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 5/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348112 | 0.84 | NPC1 (0.41) | PTGESPDE2APDE10AKDM4ENPSR1 | |
| SCHEMBL29366005 | 0.82 | PIK3CD (0.34) | PDE10ACYP2A6NPC1RAB9AMEN1 | |
| SCHEMBL121151 | 0.82 | PIK3CD (0.34) | PDE10ACYP2A6NPC1RAB9AMEN1 | |
| SCHEMBL1871032 | 0.78 | PTGES (0.38) | PTGESORAI1LMNA | |
| SCHEMBL1873473 | 0.78 | NPC1 (0.37) | PDE2APDE10ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1744858 | 0.77 | CYP2A6 (0.48) | PTGESKDM4ECYP2A6NPC1RAB9A | |
| SCHEMBL29369509 | 0.76 | NPC1 (0.44) | PDE2APDE10ANPSR1NPC1RAB9A | |
| SCHEMBL69222 | 0.76 | NPC1 (0.44) | PDE2APDE10ANPSR1NPC1RAB9A | |
| SCHEMBL13165374 | 0.76 | NPC1 (0.44) | PTGESPDE2APDE10AKDM4ENPSR1 | |
| SCHEMBL3843013 | 0.76 | PDE2A (0.43) | PTGESPDE2APDE10AKDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410026-B2 | Pyridazine fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-02 | — | — | US | claimed |
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA CROP PROTECTION AG (US) | 2011-05-12 | — | — | US | claimed |
| CN-101910149-A | Pyridazine fungicides | SYNGENTA PARTICIPATIONS AG | 2010-12-08 | — | — | CN | claimed |
| EP-2231637-A1 | PYRIDAZINE FUNGICIDES | Syngenta Participations AG (CH) | 2010-09-29 | — | — | EP | claimed |
| WO-2009090039-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-23 | — | — | WO | claimed |
| US-8410026-B2 | Pyridazine fungicides | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-02 | — | — | US | disclosed |
| EP-2231637-B1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-12-19 | — | — | EP | disclosed |
| US-20110142802-A1 | FUNGICIDAL COMPOSITIONS | SYNGENTA CROP PROTECTION, INC. (US) | 2011-06-16 | — | — | US | disclosed |
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA CROP PROTECTION AG (US) | 2011-05-12 | — | — | US | disclosed |
| CN-101910149-A | Pyridazine fungicides | SYNGENTA PARTICIPATIONS AG | 2010-12-08 | — | — | CN | disclosed |
| EP-2231637-A1 | PYRIDAZINE FUNGICIDES | Syngenta Participations AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| EP-2229057-A1 | FUNGICIDAL COMPOSITIONS | Syngenta Participations AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009090039-A1 | PYRIDAZINE FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-23 | — | — | WO | disclosed |
| WO-2009090038-A1 | FUNGICIDAL COMPOSITIONS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110142802-A1 | FUNGICIDAL COMPOSITIONS | CYP4X1, CYP1B1, CYP4B1 | PTGES 4724/4885PDE2A 2444/4885PDE10A 4236/4885 |
| US-20110112108-A1 | PYRIDAZINE FUNGICIDES | CBR3, CBR1, CYP4Z1 | PTGES 4033/4885PDE2A 750/4885PDE10A 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.