SCHEMBL1871297

SCHEMBL1871297

OC(F)C(F)(F)c1ccccc1-c1ccoc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 2/20 0.36
GPR84 Q9NQS5 1/20 0.35
SCN9A Q15858 1/20 0.35
NAT1 P18440 3/20 0.35
ERN1 O75460 1/20 0.34
MEN1 O00255 1/20 0.31
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
CETP P11597 1/20 0.31
ADRA1D P25100 1/20 0.31
ADRA1A P35348 1/20 0.31
ADRA1B P35368 1/20 0.31
MLYCD O95822 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL613277 0.73 IMPDH2 (0.37) IMPDH2GPR84NAT1ERN1MEN1
SCHEMBL1871294 0.72 IMPDH2 (0.36) IMPDH2GPR84NAT1ERN1MEN1
SCHEMBL2558874 0.66 IMPDH2 (0.46) IMPDH2GPR84NAT1ERN1MEN1
SCHEMBL5648236 0.66 ALDH1A1 (0.54) IMPDH2GPR84NAT1ERN1MEN1
SCHEMBL5781695 0.66 IMPDH2 (0.48) IMPDH2GPR84NAT1MEN1USP2
SCHEMBL7220209 0.65
SCHEMBL29140760 0.65 CA1 (0.44) MEN1ALDH1A1KMT2A
SCHEMBL26259960 0.63 IMPDH2 (0.60) IMPDH2GPR84MEN1USP2ALDH1A1
SCHEMBL26259973 0.63 IMPDH2 (0.55) IMPDH2GPR84MEN1USP2ALDH1A1
SCHEMBL395258 0.63 ALDH1A1 (0.54) IMPDH2GPR84NAT1MEN1USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496231-A1 TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER Lexicon Pharmaceuticals, Inc. (US) 2012-09-12 EP disclosed
WO-2011056916-A1 TRYPTOPHAN HYDROXYLASE INHIBITORS FOR THE TREATMENT OF CANCER LEXICON PHARMACEUTICALS, INC. (US) 2011-05-12 WO disclosed
WO-2010065333-A1 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF OSTEOPOROSIS LEXICON PHARMACEUTICALS, INC. (US) 2010-06-10 WO disclosed