Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15945437 | 0.84 | ACHE (0.35) | ACHE | |
| SCHEMBL24973987 | 0.82 | ACHE (0.46) | ALDH1A1HTTMAPTPKMKMT2A | |
| SCHEMBL24916434 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HTTMAPTPKMKMT2A | |
| SCHEMBL18712970 | 0.78 | ACHE (0.33) | ACHE | |
| SCHEMBL12017404 | 0.77 | HTR5A (0.36) | HTTKMT2AACHE | |
| SCHEMBL15947704 | 0.77 | HTR5A (0.36) | HTTKMT2AACHE | |
| SCHEMBL24713244 | 0.77 | KDM5B (0.39) | ALDH1A1HTTMAPTPKMKMT2A | |
| SCHEMBL17076744 | 0.76 | MEN1 (0.43) | ALDH1A1MAPTPKMKMT2AACHE | |
| SCHEMBL659599 | 0.76 | HPGD (0.46) | ALDH1A1HTTMAPTPKMKMT2A | |
| SCHEMBL15651587 | 0.76 | MEN1 (0.43) | ALDH1A1MAPTPKMKMT2AACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170096425-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA, INC. | 2017-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096425-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | ALDH1A1 2706/4885HTT 4246/4885MAPT 2183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.