Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3493900 | 0.83 | APP (0.52) | APPDYRK1AKDM4ELMNAMAPT | |
| SCHEMBL3493309 | 0.82 | APP (0.51) | APPDYRK1AGSK3BKDM4EMAPT | |
| SCHEMBL12170942 | 0.80 | NPC1 (0.62) | APPDYRK1AFFAR1KDM4ELMNA | |
| SCHEMBL3492630 | 0.77 | APP (0.52) | APPDYRK1AFFAR1GSK3BKDM4E | |
| SCHEMBL3491891 | 0.76 | HPGD (0.57) | APPDYRK1AGSK3BKDM4ELMNA | |
| SCHEMBL12170961 | 0.74 | NPC1 (0.58) | APPDYRK1AKDM4ELMNAMAPT | |
| SCHEMBL31214345 | 0.72 | DYRK1A (0.72) | APPDYRK1AFFAR1KDM4EALDH1A1 | |
| SCHEMBL12614654 | 0.69 | DYRK1A (0.55) | APPDYRK1AFFAR1KDM4ENPC1 | |
| SCHEMBL4713744 | 0.68 | NPC1 (0.49) | DYRK1AFFAR1KDM4EALDH1A1NPC1 | |
| SCHEMBL360534 | 0.68 | TAS1R3 (0.46) | DYRK1AFFAR1GSK3BKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611230-B2 | 1,3,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease | PTC THERAPEUTICS, INC. (US) | 2017-04-04 | — | — | US | disclosed |