Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 10/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.33 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473176 | 0.79 | ESR2 (0.57) | SPHK1ESR2CYP2C9ESR1CYP3A4 | |
| SCHEMBL15744652 | 0.77 | CYP2C9 (0.56) | SPHK1ESR2CYP2C9ESR1CYP3A4 | |
| SCHEMBL13008860 | 0.77 | CYP19A1 (0.45) | CYP2C9CYP19A1 | |
| SCHEMBL16527200 | 0.77 | HDAC1 (0.41) | ESR2CYP2C9ESR1CYP3A4 | |
| SCHEMBL25072706 | 0.76 | ALDH1A1 (0.41) | SLC18A3ESR2CYP2C9 | |
| SCHEMBL28106275 | 0.76 | SLC18A3 (0.40) | SPHK1SLC18A3ESR2CYP2C9CYP19A1 | |
| SCHEMBL4397354 | 0.76 | ESR2 (0.38) | SLC18A3ESR2CYP2C9CYP19A1ESR1 | |
| SCHEMBL12000552 | 0.76 | DRD2 (0.47) | SLC18A3ESR2CYP2C9 | |
| SCHEMBL3133672 | 0.76 | ESR2 (0.62) | ESR2CYP2C9ESR1CYP3A4 | |
| SCHEMBL17071978 | 0.75 | ESR2 (0.52) | SPHK1ESR2CYP2C9ESR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153501-A1 | GLUCAGON ANTAGONISTS | Metabasis Therapeutics, Inc. (US) | 2017-04-12 | — | — | EP | disclosed |