Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | DRD5 | P21918 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21007325 | 0.93 | CRHR1 (0.39) | HRH3CRHR1MAPTCRHBPCRHR2 | |
| SCHEMBL21301061 | 0.91 | MAPT (0.38) | HRH3CRHR1MAPTCRHBPCRHR2 | |
| SCHEMBL21301038 | 0.90 | CRHR1 (0.42) | CRHR1DRD2DRD1DRD4DRD5 | |
| SCHEMBL21006224 | 0.90 | HRH3 (0.39) | HRH3CRHR1MAPTCRHBPCRHR2 | |
| SCHEMBL18724398 | 0.89 | OGA (0.41) | HRH3CRHR1ACHEMLLT1TRPV4 | |
| SCHEMBL18724248 | 0.87 | HRH3 (0.40) | HRH3CRHR1MAPTCRHBPCRHR2 | |
| SCHEMBL18724244 | 0.87 | HRH3 (0.40) | HRH3CRHR1MAPTCRHBPCRHR2 | |
| SCHEMBL18724115 | 0.83 | TRPV4 (0.38) | HRH3ACHEMLLT1TRPV4 | |
| SCHEMBL21006132 | 0.83 | TRPV4 (0.38) | HRH3ACHEMLLT1TRPV4 | |
| SCHEMBL21301054 | 0.83 | CRHR1 (0.39) | HRH3CRHR1MAPTCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153511-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE FOR USE IN THE PREVENTION OR TREATMENT OF BLADDER/URINARY TRACT DISEASES | ASTELLAS PHARMA INC (JP) | 2019-05-15 | — | — | EP | disclosed |
| EP-3153511-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2017-04-12 | — | — | EP | disclosed |