Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 6/20 | 0.35 |
| ▸ | DRD3 | P35462 | 5/20 | 0.35 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | DRD1 | P21728 | 3/20 | 0.35 |
| ▸ | DRD5 | P21918 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21301054 | 0.94 | CRHR1 (0.39) | CRHR1DRD2CYP2D6KMT2AMAPK1 | |
| SCHEMBL18724052 | 0.90 | HRH3 (0.39) | CRHR1DRD2DRD3DRD4DRD1 | |
| SCHEMBL21300927 | 0.84 | MAPK1 (0.44) | CRHR1DRD2CYP2D6KMT2AMAPK1 | |
| SCHEMBL21007325 | 0.83 | CRHR1 (0.39) | CRHR1DRD2DRD3DRD4DRD1 | |
| SCHEMBL21301061 | 0.81 | MAPT (0.38) | CRHR1KMT2AKDM4EHSD17B10 | |
| SCHEMBL21006224 | 0.80 | HRH3 (0.39) | CRHR1KDM4E | |
| SCHEMBL18724398 | 0.79 | OGA (0.41) | CRHR1 | |
| SCHEMBL17400495 | 0.79 | MPL (0.44) | — | |
| SCHEMBL21301035 | 0.79 | CRHR1 (0.44) | CRHR1KMT2AKDM4EHSD17B10MAPK1 | |
| SCHEMBL21301033 | 0.79 | CRHR1 (0.42) | CRHR1KMT2AKDM4EHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2963036-B1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2019-08-28 | — | — | EP | disclosed |