Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.35 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724017 | 0.90 | MAP4K4 (0.38) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL18724357 | 0.89 | CRHR1 (0.37) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL21301035 | 0.88 | CRHR1 (0.44) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL21005959 | 0.87 | MEN1 (0.47) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL18724252 | 0.87 | MEN1 (0.47) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL18724315 | 0.87 | CCR2 (0.36) | CRHR1ALDH1A1KMT2ASPHK2SPHK1 | |
| SCHEMBL18724353 | 0.87 | ALDH1A1 (0.37) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL18724352 | 0.87 | ALDH1A1 (0.37) | CRHR1MEN1ALDH1A1KMT2ASPHK2 | |
| SCHEMBL18724365 | 0.82 | MPL (0.40) | CRHR1TRPA1TRPV4MPLVNN1 | |
| SCHEMBL21006636 | 0.82 | MPL (0.40) | CRHR1TRPA1TRPV4MPLVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3153511-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2017-04-12 | — | — | EP | disclosed |