SCHEMBL18732425

SCHEMBL18732425

Clc1ccc2c(c1)-c1ccc3c(sc4ccccc43)c1C21c2ccccc2C2(c3ccccc3-c3ccccc32)c2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.39
ALOX5 P09917 1/20 0.37
KDM4E B2RXH2 1/20 0.35
PRKDC P78527 3/20 0.33
PARP14 Q460N5 1/20 0.33
MAPT P10636 4/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
RXFP1 Q9HBX9 1/20 0.32
AKR1A1 P14550 1/20 0.32
AKR1B1 P15121 1/20 0.32
S100A4 P26447 1/20 0.31
MAOB P27338 1/20 0.30
F10 P00742 1/20 0.30
TP53 P04637 1/20 0.30
GPR3 P46089 1/20 0.30
EGFR P00533 1/20 0.30
IGF1R P08069 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18732424 0.94 ALOX5 (0.38) PDK2ALOX5KDM4EPRKDCPARP14
SCHEMBL22930729 0.89 ALOX5 (0.41) ALOX5KDM4EPRKDCPARP14MAPT
SCHEMBL18156883 0.86 ALOX5 (0.43) ALOX5KDM4EPRKDCPARP14MAPT
SCHEMBL18731726 0.85 PDK2 (0.38) PDK2ALOX5KDM4EPRKDCPARP14
SCHEMBL18732421 0.84 PDK2 (0.37) PDK2ALOX5PRKDCPARP14MAPT
SCHEMBL18731831 0.84 PDK2 (0.43) PDK2ALOX5KDM4EPRKDCPARP14
SCHEMBL18731722 0.83 PDK2 (0.36) PDK2ALOX5KDM4EPRKDCPARP14
SCHEMBL18732171 0.83 KDM4E (0.41) PDK2KDM4EMAPTALDH1A1HPGD
SCHEMBL16250099 0.82 PDK2 (0.37) PDK2ALOX5KDM4EPRKDCPARP14
SCHEMBL18732203 0.82 ALOX5 (0.35) PDK2ALOX5PRKDCPARP14GPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3345982-B1 DOUBLE SPIRO-TYPE COMPOUND AND ORGANIC LIGHT EMITTING DIODE COMPRISING SAME LG CHEMICAL LTD (KR) 2020-03-18 EP disclosed
WO-2017061810-A1 DOUBLE SPIRO-TYPE COMPOUND AND ORGANIC LIGHT EMITTING DIODE COMPRISING SAME 주식회사 엘지화학 2017-04-13 WO disclosed