Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL735835 | 0.85 | NPY5R (0.47) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL17319026 | 0.81 | MEN1 (0.39) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL737428 | 0.78 | MEN1 (0.46) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL17319083 | 0.77 | SIGMAR1 (0.66) | KMT2AOPRM1KCNH2SIGMAR1 | |
| SCHEMBL18696034 | 0.76 | NPY5R (0.36) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL17324916 | 0.76 | NPY5R (0.36) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL18695850 | 0.75 | OPRM1 (0.36) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL18695851 | 0.75 | OPRM1 (0.36) | MEN1KMT2AHTR6OPRM1OPRL1 | |
| SCHEMBL17324918 | 0.72 | OPRM1 (0.48) | MEN1KMT2AOPRM1OPRL1KCNH2 | |
| SCHEMBL17319142 | 0.72 | MEN1 (0.37) | MEN1KMT2AHTR6OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200339597-A1 | ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2020-10-29 | — | — | US | disclosed |
| US-10703765-B2 | Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-07-07 | — | — | US | disclosed |
| US-20170101420-A1 | ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2017-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703765-B2 | Alkyl and aryl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain | OPRD1, SIGMAR1, OPRM1 | MEN1 4822/4885KMT2A 4663/4885HTR6 275/4885 |
| US-20170101420-A1 | ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, SIGMAR1, OPRM1 | MEN1 4822/4885KMT2A 4663/4885HTR6 275/4885 |
| US-20200339597-A1 | ALKYL AND ARYL DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN | OPRD1, SIGMAR1, OPRM1 | MEN1 4822/4885KMT2A 4663/4885HTR6 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.