Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 14/20 | 0.67 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.67 |
| ▸ | BCHE | P06276 | 6/20 | 0.60 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.54 |
| ▸ | CTSD | P07339 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7310941 | 0.93 | BACE1 (0.56) | BACE1SLC6A11BCHE | |
| SCHEMBL7610032 | 0.87 | BACE1 (0.71) | BACE1SLC6A11BCHE | |
| SCHEMBL7610027 | 0.87 | BACE1 (0.71) | BACE1SLC6A11BCHE | |
| SCHEMBL8577646 | 0.86 | NPC1 (0.53) | BACE1SLC6A11BACE2CTSD | |
| SCHEMBL5400472 | 0.85 | BACE1 (0.74) | BACE1BCHEBACE2CTSD | |
| SCHEMBL5380143 | 0.85 | BACE1 (0.77) | BACE1BCHECTSD | |
| Hydrochloric Acid SCHEMBL5382955 | 0.84 | BACE1 (0.75) | BACE1BCHECTSD | |
| SCHEMBL8729415 | 0.83 | BACE1 (0.67) | BACE1SLC6A11BCHE | |
| SCHEMBL6809872 | 0.82 | CTRB1 (0.55) | — | |
| SCHEMBL6814426 | 0.82 | CTRB1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066742-A1 | BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE | JORTAN PHARMACEUTICALS INC. (US) | 2017-04-20 | — | — | WO | claimed |
| WO-2017066742-A1 | BACE-2 INHIBITORY COMPOUNDS AND RELATED METHODS OF USE | JORTAN PHARMACEUTICALS INC. (US) | 2017-04-20 | — | — | WO | disclosed |