Hydrochloric Acid

Hydrochloric Acid

SCHEMBL18740652

C[n+]1ccc(N(c2cc[n+](C)cc2)c2cc[n+](C)cc2)cc1.[Cl-].[Cl-].[Cl-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.34
HDAC8 Q9BY41 6/20 0.46
PABPC1 P11940 1/20 0.42
APOBEC3A P31941 1/20 0.42
EIF4H Q15056 1/20 0.42
APOBEC3G Q9HC16 1/20 0.42
SLC22A2 O15244 1/20 0.42
SLC22A1 O15245 1/20 0.42
SLC22A3 O75751 1/20 0.42
SLC6A4 P31645 1/20 0.42
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
LMNA P02545 1/20 0.40
MAPT P10636 1/20 0.40
ALPG P10696 1/20 0.40
THRB P10828 1/20 0.40
HTT P42858 1/20 0.40
GFER P55789 1/20 0.40
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL18740611 0.95 HDAC8 (0.42) HDAC8PABPC1APOBEC3AEIF4HAPOBEC3G
Fluoride Ion SCHEMBL18740610 0.94 HDAC8 (0.46) HDAC8PABPC1APOBEC3AEIF4HAPOBEC3G
Hydrochloric Acid SCHEMBL18730818 0.86 HDAC8 (0.36) HDAC8PABPC1APOBEC3AEIF4HAPOBEC3G
Hydrochloric Acid SCHEMBL18730815 0.81 HDAC8 (0.36) HDAC8PABPC1APOBEC3AEIF4HAPOBEC3G
Hydrochloric Acid SCHEMBL3748847 0.80 ALDH1A1 (0.59) HDAC8PABPC1APOBEC3AEIF4HAPOBEC3G
Iodide SCHEMBL18740643 0.78 HDAC8 (0.42) HDAC8SLC22A2SLC22A1SLC22A3SLC6A4
Fluoride Ion SCHEMBL18740632 0.78 HDAC8 (0.42) HDAC8SLC22A2SLC22A1SLC22A3SLC6A4
SCHEMBL1940232 0.77 ALDH1A1 (0.61) HDAC8SLC22A2SLC22A1SLC22A3SLC6A4
Hydrochloric Acid SCHEMBL18740642 0.76 SLC22A2 (0.39) HDAC8PABPC1EIF4HSLC22A2SLC22A1
SCHEMBL17327854 0.76 ALDH1A1 (0.50) HDAC8MEN1ALDH1A1MAPTGFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017065702-A1 METHOD OF SYNTHESIZING AND IDENTIFICATION OF THE NEW COMPONENT 4,4'-AZANEDIYLBIS(1-METHYLPYRIDINIUM) CHLORIDE 4,4',4''- NITRILOTRIS-(1-METHYLPYRIDINIUM) CHLORIDE AND ITS DERIVATIVE HERBICIDAL EFFECTS DECHDAMRONGWUT, Dujdao (TH) 2017-04-20 WO disclosed