Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | CHKA | P35790 | 6/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940232 | 0.97 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Iodide SCHEMBL3748614 | 0.94 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL12315045 | 0.82 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Iodide SCHEMBL1885085 | 0.80 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL1435652 | 0.80 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL1435655 | 0.80 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL28626066 | 0.80 | MEN1 (0.92) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL28626064 | 0.80 | MEN1 (0.92) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| Hydrochloric Acid SCHEMBL18740652 | 0.80 | HDAC8 (0.46) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL13614031 | 0.77 | MAPT (0.53) | ALDH1A1SMN1; SMN2LMNAHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195330-B1 | Method and agent for refolding proteins | MERCK PATENT GMBH (DE) | 2013-03-13 | — | — | EP | disclosed |
| US-20100292447-A1 | METHOD AND AGENT FOR REFOLDING PROTEINS | MERCK PATENT GESELLSCHAFT (DE) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292447-A1 | METHOD AND AGENT FOR REFOLDING PROTEINS | HSPA5, MRPL21, HSPBP1 | ALDH1A1 3592/4885SMN1; SMN2 1189/4885LMNA 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.